Anafranil for Premature Ejaculation

How To Use Anafranil for Premature Ejaculation

Here’s what you need to know about using Anafranil for premature ejaculation

Anafranil is the brand name for clomipramine. But unlike Prozac and Paxil, it’s not an SSRI antidepressant. It’s a tricyclic antidepressant, and they’re slightly different.

It works by regulating the levels of serotonin (a chemical that controls ejaculation) in the brain. Much like the SSRI antidepressants used for premature ejaculation treatment (Paxil, Prozac, Zoloft).

For more information on those SSRI antidepressants see

In men who suffer from premature ejaculation, Anafranil increases the levels of serotonin, and enables him to delay his ejaculation and last longer.

Your doctor will probably tell to first try to take Anafranil as needed. That is, you take it only when you plan to have sex. In this case, usual dose is 50 mg, 2-12 hours before sex.

If that fails, than your doctor might recommend taking Anafranil on a daily basis. Usually 50 mg per day.

Most doctors will probably first prescribe you the one of the SSRI antidepressants (Paxil, Prozac, or Zoloft) because they tend to have fewer side effects than tricyclic antidepressants (Anafranil).

For more information see:

  • How to use Prozac for premature ejaculation
  • How to use Paxil for premature ejaculation
  • How To use Zoloft for  premature ejaculation

But, many investigators find that Anafranil (clomipramine) is more effective for premature ejaculation than SSRI antidepressants.

Anafranil is a prescription-only drug. Nevertheless some online pharmacies sell it (illegally) without prescription. DO NOT use Anafranil without medical supervision.

If you don’t know what you’re doing, things can go wrong. And you can damage your health instead of improving your ejaculation time.

Here are some general warnings and precautions when using Anafranil for premature ejaculation…

You should use Anafranil with caution if…

  • you have problems with liver or kidneys
  • you have Parkinson disease,
  • you have a history of seizure disorders
  • you have unstable hearth disease

You should not use Anafranil with…

  • alcohol
  • other antidepressants and sedatives
  • and some other medications (check with your doctor)

Here’s the medical description of Anafranil (clomipramine)…


Drug Name
Clomipramine (Anafranil) — Inhibits membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. These actions are believed to be responsible for its antidepressant activity. Inhibition of serotonin probably gives the SSRI-like activity that produces side effects (eg, inhibition of ejaculation).

Adult Dose
50 mg PO 2-12 h before sexual relations; alternatively, 50 mg/d PO

Pediatric Dose
Not established

Documented hypersensitivity; recent MI; do not use within 14 d of MAOIs administration

Barbiturates, phenytoin, and carbamazepine decrease effects; increases effects of anticholinergics, sympathomimetics, alcohol, and CNS depressants; increased toxicity of MAOIs

C – Safety for use during pregnancy has not been established.

Caution in preexisting seizure disorders; recent MI or unstable heart disease; in hepatic or renal impairment, adjust dose accordingly; constipation; glaucoma; hyponatremia

Copyright © WebMD, By Mark Jeffrey Noble, MD, Urologic Institute, Cleveland Clinic Foundation, Retrieved from:

You should never use prescription drugs without medical supervision. Using  Anafranil for premature ejaculation is no exception.

Ejaculate Too Quickly?


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by How To Use Paxil for Premature Ejaculation on February 22, 2012 at 10:37 am. Reply #

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by How To Use Prozac For Premature Ejaculation on February 22, 2012 at 10:38 am. Reply #

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by DON'T Take Any Premature Ejaculation Pills Until You See This! on February 22, 2012 at 11:27 am. Reply #

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by Denis Portela on June 20, 2012 at 3:47 am. Reply #

wat about people who are 19years below how many mg should they take, is it still 50mg

by Sarince on January 3, 2015 at 2:35 pm. Reply #

I think this is the best medicine for PME way ahead of any ssri even 25mg is greatly effective in majorty more over it do not inhibit libido actually it increase it may be due to increase confidence and control over ejaculation

by Raghav on March 26, 2015 at 11:21 pm. Reply #

Yeh its very effective drug, but i want to know can a person take it regularly for PME as teatment….?

by Anonymous on November 5, 2015 at 7:46 pm. Reply #

Premature ejaculation is when you have no coortnl over your ejaculations. So not necessarily, that’s just means you’re speedy (it’s not like you have to wait for you to finish when you’re doing it with you). And it’s OK that you’re speedy with Rosie and her 5 sisters, as long as you’re not speedy with Miss Right.

by Janice on June 2, 2012 at 12:02 pm. Reply #

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