Anafranil for Premature Ejaculation

How To Use Anafranil for Premature Ejaculation

Here’s what you need to know about using Anafranil for premature ejaculation

Anafranil is the brand name for clomipramine. But unlike Prozac and Paxil, it’s not an SSRI antidepressant. It’s a tricyclic antidepressant, and they’re slightly different.

It works by regulating the levels of serotonin (a chemical that controls ejaculation) in the brain. Much like the SSRI antidepressants used for premature ejaculation treatment (Paxil, Prozac, Zoloft).

For more information on those SSRI antidepressants see

In men who suffer from premature ejaculation, Anafranil increases the levels of serotonin, and enables him to delay his ejaculation and last longer.

Your doctor will probably tell to first try to take Anafranil as needed. That is, you take it only when you plan to have sex. In this case, usual dose is 50 mg, 2-12 hours before sex.

If that fails, than your doctor might recommend taking Anafranil on a daily basis. Usually 50 mg per day.

Most doctors will probably first prescribe you the one of the SSRI antidepressants (Paxil, Prozac, or Zoloft) because they tend to have fewer side effects than tricyclic antidepressants (Anafranil).

For more information see:

  • How to use Prozac for premature ejaculation
  • How to use Paxil for premature ejaculation
  • How To use Zoloft for  premature ejaculation

But, many investigators find that Anafranil (clomipramine) is more effective for premature ejaculation than SSRI antidepressants.

Anafranil is a prescription-only drug. Nevertheless some online pharmacies sell it (illegally) without prescription. DO NOT use Anafranil without medical supervision.

If you don’t know what you’re doing, things can go wrong. And you can damage your health instead of improving your ejaculation time.

Here are some general warnings and precautions when using Anafranil for premature ejaculation…

You should use Anafranil with caution if…

  • you have problems with liver or kidneys
  • you have Parkinson disease,
  • you have a history of seizure disorders
  • you have unstable hearth disease

You should not use Anafranil with…

  • alcohol
  • other antidepressants and sedatives
  • and some other medications (check with your doctor)

Here’s the medical description of Anafranil (clomipramine)…


Drug Name
Clomipramine (Anafranil) — Inhibits membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. These actions are believed to be responsible for its antidepressant activity. Inhibition of serotonin probably gives the SSRI-like activity that produces side effects (eg, inhibition of ejaculation).

Adult Dose
50 mg PO 2-12 h before sexual relations; alternatively, 50 mg/d PO

Pediatric Dose
Not established

Documented hypersensitivity; recent MI; do not use within 14 d of MAOIs administration

Barbiturates, phenytoin, and carbamazepine decrease effects; increases effects of anticholinergics, sympathomimetics, alcohol, and CNS depressants; increased toxicity of MAOIs

C – Safety for use during pregnancy has not been established.

Caution in preexisting seizure disorders; recent MI or unstable heart disease; in hepatic or renal impairment, adjust dose accordingly; constipation; glaucoma; hyponatremia

Copyright © WebMD, By Mark Jeffrey Noble, MD, Urologic Institute, Cleveland Clinic Foundation, Retrieved from:

You should never use prescription drugs without medical supervision. Using  Anafranil for premature ejaculation is no exception.

Ejaculate Too Quickly?


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by How To Use Paxil for Premature Ejaculation on February 22, 2012 at 10:37 am. Reply #

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by Denis Portela on June 20, 2012 at 3:47 am. Reply #

wat about people who are 19years below how many mg should they take, is it still 50mg

by Sarince on January 3, 2015 at 2:35 pm. Reply #

I think this is the best medicine for PME way ahead of any ssri even 25mg is greatly effective in majorty more over it do not inhibit libido actually it increase it may be due to increase confidence and control over ejaculation

by Raghav on March 26, 2015 at 11:21 pm. Reply #

Yeh its very effective drug, but i want to know can a person take it regularly for PME as teatment….?

by Anonymous on November 5, 2015 at 7:46 pm. Reply #

I hope anafranil will stop dis premature ejaculations thanks

by Emmanuel Ekeocha on January 3, 2016 at 3:08 am. Reply #

I like most your comment, Male sexual problem is a gig problem in present time. Man who is living with this problem, unable to satisfy his partner so his partner blames him about his sexual health. You have not be worry if you suffering premature ejaculation or weak in loving performance in bed. Walk a step towards natural supplements to treat it naturally

by john on January 5, 2016 at 7:04 am. Reply #

How much wil anafranils costs me? N wet can i find them

by Vince on March 8, 2016 at 12:05 am. Reply #

It’s cool, anafranil is super cos first I was weak but now I the boss in bed. My premature ejaculation stop like magic. Thanks.

by David Calabash on March 26, 2016 at 6:08 pm. Reply #

PE was a big problem for me, and when i read about Anafranil and its side effects i hesitated for many days and was afraid to cause something much worse to my health than the PE problem which i never could keep for more than 40 to 50 secondes, and even sometimes used to Ejaculation before any penetration. OMG that was so embarassing.
i remember the first day i decided to just go for Anafranil and give it a try, i didn’t even ask any doctor, i faked a prescription and bought it from the Pharmacy (25mg); then took the first pill… Oh yes they were scarry side effects i experienced; dizziness as if the ground i was walking on was waving like a sea, and my head felt like some VERY tight belt was around it as if my brain was being squeezed..
the side effects lasted for about 3 to 4 hours, but i felt so sleepy all the time and kept yawning every 5 minutes for more than two days..
but for my PE problem; oh it just disappeared like a miracle, from 40-50 secondes to 12-15 minutes from the very first 25mg i ever took.. which was the last too because the side efects i experiences got me scared for my health and my brain..
i kept having sex for the next 3 days for more than 3 times a day and the effect of Anafranil kept working til the fourth day (always more than 10 minutes before ejaculation).
after a few weeks i decided to just take it again; only this time i took only half of the 25mg pill, which is about 13mg only; and honestly i worked like magic, my PE was gone immediately and 13mg was not that much to cause any side effects at all, it’s been almost a week now that i’m taking 13mg a day of Anafranil; no side effects and my partner is more than happy with our sexual life.
i don’t know if my PE problem will be cured permanently if i continue to take these 13mg a day for like a month or more.

by Faissal on May 10, 2016 at 1:28 pm. Reply #

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