Anafranil for Premature Ejaculation

How To Use Anafranil for Premature Ejaculation


Here’s what you need to know about using Anafranil for premature ejaculation

Anafranil is the brand name for clomipramine. But unlike Prozac and Paxil, it’s not an SSRI antidepressant. It’s a tricyclic antidepressant, and they’re slightly different.

It works by regulating the levels of serotonin (a chemical that controls ejaculation) in the brain. Much like the SSRI antidepressants used for premature ejaculation treatment (Paxil, Prozac, Zoloft).

For more information on those SSRI antidepressants see

In men who suffer from premature ejaculation, Anafranil increases the levels of serotonin, and enables him to delay his ejaculation and last longer.

Your doctor will probably tell to first try to take Anafranil as needed. That is, you take it only when you plan to have sex. In this case, usual dose is 50 mg, 2-12 hours before sex.

If that fails, than your doctor might recommend taking Anafranil on a daily basis. Usually 50 mg per day.

Most doctors will probably first prescribe you the one of the SSRI antidepressants (Paxil, Prozac, or Zoloft) because they tend to have fewer side effects than tricyclic antidepressants (Anafranil).

For more information see:

  • How to use Prozac for premature ejaculation
  • How to use Paxil for premature ejaculation
  • How To use Zoloft for  premature ejaculation

But, many investigators find that Anafranil (clomipramine) is more effective for premature ejaculation than SSRI antidepressants.

Anafranil is a prescription-only drug. Nevertheless some online pharmacies sell it (illegally) without prescription. DO NOT use Anafranil without medical supervision.

If you don’t know what you’re doing, things can go wrong. And you can damage your health instead of improving your ejaculation time.

Here are some general warnings and precautions when using Anafranil for premature ejaculation…

You should use Anafranil with caution if…

  • you have problems with liver or kidneys
  • you have Parkinson disease,
  • you have a history of seizure disorders
  • you have unstable hearth disease

You should not use Anafranil with…

  • alcohol
  • other antidepressants and sedatives
  • and some other medications (check with your doctor)

Here’s the medical description of Anafranil (clomipramine)…

CLOMIPRAMINE (ANAFRANIL)

Drug Name
Clomipramine (Anafranil) — Inhibits membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. These actions are believed to be responsible for its antidepressant activity. Inhibition of serotonin probably gives the SSRI-like activity that produces side effects (eg, inhibition of ejaculation).

Adult Dose
50 mg PO 2-12 h before sexual relations; alternatively, 50 mg/d PO

Pediatric Dose
Not established

Contraindications
Documented hypersensitivity; recent MI; do not use within 14 d of MAOIs administration

Interactions
Barbiturates, phenytoin, and carbamazepine decrease effects; increases effects of anticholinergics, sympathomimetics, alcohol, and CNS depressants; increased toxicity of MAOIs

Pregnancy
C – Safety for use during pregnancy has not been established.

Precautions
Caution in preexisting seizure disorders; recent MI or unstable heart disease; in hepatic or renal impairment, adjust dose accordingly; constipation; glaucoma; hyponatremia

Copyright © WebMD, By Mark Jeffrey Noble, MD, Urologic Institute, Cleveland Clinic Foundation, Retrieved from: http://www.emedicine.com/med/topic643.htm

You should never use prescription drugs without medical supervision. Using  Anafranil for premature ejaculation is no exception.

Ejaculate Too Quickly?

23 comments

[…] have found that Anafranil works better for premature ejaculation than many SSRI antidepressants. However, that comes at a price because Anafranil usually has more […]

by How To Use Paxil for Premature Ejaculation on February 22, 2012 at 10:37 am. Reply #

[…] For more information see “How to Use Anafranil for Premature Ejaculation“. […]

by How To Use Prozac For Premature Ejaculation on February 22, 2012 at 10:38 am. Reply #

[…] Anafranil  for premature ejaculation […]

by DON'T Take Any Premature Ejaculation Pills Until You See This! on February 22, 2012 at 11:27 am. Reply #

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by Denis Portela on June 20, 2012 at 3:47 am. Reply #

wat about people who are 19years below how many mg should they take, is it still 50mg

by Sarince on January 3, 2015 at 2:35 pm. Reply #

I think this is the best medicine for PME way ahead of any ssri even 25mg is greatly effective in majorty more over it do not inhibit libido actually it increase it may be due to increase confidence and control over ejaculation

by Raghav on March 26, 2015 at 11:21 pm. Reply #

Yeh its very effective drug, but i want to know can a person take it regularly for PME as teatment….?

by Anonymous on November 5, 2015 at 7:46 pm. Reply #

I hope anafranil will stop dis premature ejaculations thanks

by Emmanuel Ekeocha on January 3, 2016 at 3:08 am. Reply #

I like most your comment, Male sexual problem is a gig problem in present time. Man who is living with this problem, unable to satisfy his partner so his partner blames him about his sexual health. You have not be worry if you suffering premature ejaculation or weak in loving performance in bed. Walk a step towards natural supplements to treat it naturally

by john on January 5, 2016 at 7:04 am. Reply #

How much wil anafranils costs me? N wet can i find them

by Vince on March 8, 2016 at 12:05 am. Reply #

It’s cool, anafranil is super cos first I was weak but now I the boss in bed. My premature ejaculation stop like magic. Thanks.

by David Calabash on March 26, 2016 at 6:08 pm. Reply #

PE was a big problem for me, and when i read about Anafranil and its side effects i hesitated for many days and was afraid to cause something much worse to my health than the PE problem which i never could keep for more than 40 to 50 secondes, and even sometimes used to Ejaculation before any penetration. OMG that was so embarassing.
i remember the first day i decided to just go for Anafranil and give it a try, i didn’t even ask any doctor, i faked a prescription and bought it from the Pharmacy (25mg); then took the first pill… Oh yes they were scarry side effects i experienced; dizziness as if the ground i was walking on was waving like a sea, and my head felt like some VERY tight belt was around it as if my brain was being squeezed..
the side effects lasted for about 3 to 4 hours, but i felt so sleepy all the time and kept yawning every 5 minutes for more than two days..
but for my PE problem; oh it just disappeared like a miracle, from 40-50 secondes to 12-15 minutes from the very first 25mg i ever took.. which was the last too because the side efects i experiences got me scared for my health and my brain..
i kept having sex for the next 3 days for more than 3 times a day and the effect of Anafranil kept working til the fourth day (always more than 10 minutes before ejaculation).
after a few weeks i decided to just take it again; only this time i took only half of the 25mg pill, which is about 13mg only; and honestly i worked like magic, my PE was gone immediately and 13mg was not that much to cause any side effects at all, it’s been almost a week now that i’m taking 13mg a day of Anafranil; no side effects and my partner is more than happy with our sexual life.
i don’t know if my PE problem will be cured permanently if i continue to take these 13mg a day for like a month or more.

by Faissal on May 10, 2016 at 1:28 pm. Reply #

This pill turned me into a porn star. My girl friend was amazed and loved me even more. I did the 25 mg about 4 hours before sex. Make sure and eat well after taking it and be relaxed. The yawning and slight dizziness is negligible, keeping in mind that you’re going to war in bed. Lol. However, do not over use the product. I use it only for impression sex, so that my girlfriend will have the understood bed respect for me. So for normal days of sex, she won’t mind a 5 – 10 minute penetration episode. Remember to kiss, and caress and suck your woman. It pleases women when you do this. Then a typical PE would be totally acceptable by her. I should charge you guys for this advice. Ha ha ha ha ha.

by Addithebliss on June 10, 2016 at 12:26 pm. Reply #

I also do suffer from premature ejaculating but anafranil did wonders to and now I am no longer afraid of how long am gonna last when having sex. How long does the effect actually last in the body.

by Dan on June 19, 2016 at 5:59 pm. Reply #

Taking Anafranil to prevent PE, first one need to consider the presence of the opposite sex. In the absence of the female or denial of sex can be dangerous. Its also dangerous to take anafranil along with alcohol. To take anafranil, 2hrs before sex and eat solid food and drink enough water. For me, I take 10mg

by Toni on July 7, 2016 at 1:56 pm. Reply #

Anafranil Works magic.go for it pals

by skaris on August 27, 2016 at 5:44 pm. Reply #

will continuous use of Anafranil cause weaken sex drive/libido or lead to ED permanently? Can it be taken with Sildanafil/Tadanafil/Vardanafil?

by GH on September 3, 2016 at 6:41 am. Reply #

I have read so much about this drug oo…I pray it works for me cause my PE is really embarrassing me tho

by eleniyan on September 8, 2016 at 9:06 pm. Reply #

Anafranil warns very much

by Dorman on October 13, 2016 at 12:04 am. Reply #

Can an ulcer patient use Anafranil for sexual intercourse

by Emmanuel on October 30, 2016 at 8:27 am. Reply #

Sorry buddy, I can’t tell you anything with any reasonable degree of certainty. I strongly advise to talk to your doctor about this. Good luck.

by Frank DeLuca on November 2, 2016 at 5:19 pm. Reply #

Anafranil turned me to a sex monster,i had sex for six rounds with each lasting about 20mins minimum.

by emeka on November 16, 2016 at 4:19 am. Reply #

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