Anafranil for Premature Ejaculation

How To Use Anafranil for Premature Ejaculation

Here’s what you need to know about using Anafranil for premature ejaculation

Anafranil is the brand name for clomipramine. But unlike Prozac and Paxil, it’s not an SSRI antidepressant. It’s a tricyclic antidepressant, and they’re slightly different.

It works by regulating the levels of serotonin (a chemical that controls ejaculation) in the brain. Much like the SSRI antidepressants used for premature ejaculation treatment (Paxil, Prozac, Zoloft).

For more information on those SSRI antidepressants see

In men who suffer from premature ejaculation, Anafranil increases the levels of serotonin, and enables him to delay his ejaculation and last longer.

Your doctor will probably tell to first try to take Anafranil as needed. That is, you take it only when you plan to have sex. In this case, usual dose is 50 mg, 2-12 hours before sex.

If that fails, than your doctor might recommend taking Anafranil on a daily basis. Usually 50 mg per day.

Most doctors will probably first prescribe you the one of the SSRI antidepressants (Paxil, Prozac, or Zoloft) because they tend to have fewer side effects than tricyclic antidepressants (Anafranil).

For more information see:

  • How to use Prozac for premature ejaculation
  • How to use Paxil for premature ejaculation
  • How To use Zoloft for  premature ejaculation

But, many investigators find that Anafranil (clomipramine) is more effective for premature ejaculation than SSRI antidepressants.

Anafranil is a prescription-only drug. Nevertheless some online pharmacies sell it (illegally) without prescription. DO NOT use Anafranil without medical supervision.

If you don’t know what you’re doing, things can go wrong. And you can damage your health instead of improving your ejaculation time.

Here are some general warnings and precautions when using Anafranil for premature ejaculation…

You should use Anafranil with caution if…

  • you have problems with liver or kidneys
  • you have Parkinson disease,
  • you have a history of seizure disorders
  • you have unstable hearth disease

You should not use Anafranil with…

  • alcohol
  • other antidepressants and sedatives
  • and some other medications (check with your doctor)

Here’s the medical description of Anafranil (clomipramine)…


Drug Name
Clomipramine (Anafranil) — Inhibits membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. These actions are believed to be responsible for its antidepressant activity. Inhibition of serotonin probably gives the SSRI-like activity that produces side effects (eg, inhibition of ejaculation).

Adult Dose
50 mg PO 2-12 h before sexual relations; alternatively, 50 mg/d PO

Pediatric Dose
Not established

Documented hypersensitivity; recent MI; do not use within 14 d of MAOIs administration

Barbiturates, phenytoin, and carbamazepine decrease effects; increases effects of anticholinergics, sympathomimetics, alcohol, and CNS depressants; increased toxicity of MAOIs

C – Safety for use during pregnancy has not been established.

Caution in preexisting seizure disorders; recent MI or unstable heart disease; in hepatic or renal impairment, adjust dose accordingly; constipation; glaucoma; hyponatremia

Copyright © WebMD, By Mark Jeffrey Noble, MD, Urologic Institute, Cleveland Clinic Foundation, Retrieved from:

You should never use prescription drugs without medical supervision. Using  Anafranil for premature ejaculation is no exception.

Read this:


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by How To Use Paxil for Premature Ejaculation on February 22, 2012 at 10:37 am. Reply #

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by How To Use Prozac For Premature Ejaculation on February 22, 2012 at 10:38 am. Reply #

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by DON'T Take Any Premature Ejaculation Pills Until You See This! on February 22, 2012 at 11:27 am. Reply #

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by Denis Portela on June 20, 2012 at 3:47 am. Reply #

wat about people who are 19years below how many mg should they take, is it still 50mg

by Sarince on January 3, 2015 at 2:35 pm. Reply #

I think this is the best medicine for PME way ahead of any ssri even 25mg is greatly effective in majorty more over it do not inhibit libido actually it increase it may be due to increase confidence and control over ejaculation

by Raghav on March 26, 2015 at 11:21 pm. Reply #

Yeh its very effective drug, but i want to know can a person take it regularly for PME as teatment….?

by Anonymous on November 5, 2015 at 7:46 pm. Reply #

I hope anafranil will stop dis premature ejaculations thanks

by Emmanuel Ekeocha on January 3, 2016 at 3:08 am. Reply #

I like most your comment, Male sexual problem is a gig problem in present time. Man who is living with this problem, unable to satisfy his partner so his partner blames him about his sexual health. You have not be worry if you suffering premature ejaculation or weak in loving performance in bed. Walk a step towards natural supplements to treat it naturally

by john on January 5, 2016 at 7:04 am. Reply #

How much wil anafranils costs me? N wet can i find them

by Vince on March 8, 2016 at 12:05 am. Reply #

It’s cool, anafranil is super cos first I was weak but now I the boss in bed. My premature ejaculation stop like magic. Thanks.

by David Calabash on March 26, 2016 at 6:08 pm. Reply #

PE was a big problem for me, and when i read about Anafranil and its side effects i hesitated for many days and was afraid to cause something much worse to my health than the PE problem which i never could keep for more than 40 to 50 secondes, and even sometimes used to Ejaculation before any penetration. OMG that was so embarassing.
i remember the first day i decided to just go for Anafranil and give it a try, i didn’t even ask any doctor, i faked a prescription and bought it from the Pharmacy (25mg); then took the first pill… Oh yes they were scarry side effects i experienced; dizziness as if the ground i was walking on was waving like a sea, and my head felt like some VERY tight belt was around it as if my brain was being squeezed..
the side effects lasted for about 3 to 4 hours, but i felt so sleepy all the time and kept yawning every 5 minutes for more than two days..
but for my PE problem; oh it just disappeared like a miracle, from 40-50 secondes to 12-15 minutes from the very first 25mg i ever took.. which was the last too because the side efects i experiences got me scared for my health and my brain..
i kept having sex for the next 3 days for more than 3 times a day and the effect of Anafranil kept working til the fourth day (always more than 10 minutes before ejaculation).
after a few weeks i decided to just take it again; only this time i took only half of the 25mg pill, which is about 13mg only; and honestly i worked like magic, my PE was gone immediately and 13mg was not that much to cause any side effects at all, it’s been almost a week now that i’m taking 13mg a day of Anafranil; no side effects and my partner is more than happy with our sexual life.
i don’t know if my PE problem will be cured permanently if i continue to take these 13mg a day for like a month or more.

by Faissal on May 10, 2016 at 1:28 pm. Reply #

This pill turned me into a porn star. My girl friend was amazed and loved me even more. I did the 25 mg about 4 hours before sex. Make sure and eat well after taking it and be relaxed. The yawning and slight dizziness is negligible, keeping in mind that you’re going to war in bed. Lol. However, do not over use the product. I use it only for impression sex, so that my girlfriend will have the understood bed respect for me. So for normal days of sex, she won’t mind a 5 – 10 minute penetration episode. Remember to kiss, and caress and suck your woman. It pleases women when you do this. Then a typical PE would be totally acceptable by her. I should charge you guys for this advice. Ha ha ha ha ha.

by Addithebliss on June 10, 2016 at 12:26 pm. Reply #


by SAL on June 29, 2017 at 5:12 am. Reply #

I also do suffer from premature ejaculating but anafranil did wonders to and now I am no longer afraid of how long am gonna last when having sex. How long does the effect actually last in the body.

by Dan on June 19, 2016 at 5:59 pm. Reply #

i kind of addicted to T M if I didn’t take T M I can’t enjoy sex to my satisfaction and nw T M is making me weak dat y I wan to gv a try to anafranil

by capy on September 7, 2017 at 10:36 pm. Reply #

Taking Anafranil to prevent PE, first one need to consider the presence of the opposite sex. In the absence of the female or denial of sex can be dangerous. Its also dangerous to take anafranil along with alcohol. To take anafranil, 2hrs before sex and eat solid food and drink enough water. For me, I take 10mg

by Toni on July 7, 2016 at 1:56 pm. Reply #

Anafranil Works magic.go for it pals

by skaris on August 27, 2016 at 5:44 pm. Reply #

will continuous use of Anafranil cause weaken sex drive/libido or lead to ED permanently? Can it be taken with Sildanafil/Tadanafil/Vardanafil?

by GH on September 3, 2016 at 6:41 am. Reply #

I have read so much about this drug oo…I pray it works for me cause my PE is really embarrassing me tho

by eleniyan on September 8, 2016 at 9:06 pm. Reply #

Anafranil warns very much

by Dorman on October 13, 2016 at 12:04 am. Reply #

Can an ulcer patient use Anafranil for sexual intercourse

by Emmanuel on October 30, 2016 at 8:27 am. Reply #

Sorry buddy, I can’t tell you anything with any reasonable degree of certainty. I strongly advise to talk to your doctor about this. Good luck.

by Frank DeLuca on November 2, 2016 at 5:19 pm. Reply #

Anafranil turned me to a sex monster,i had sex for six rounds with each lasting about 20mins minimum.

by emeka on November 16, 2016 at 4:19 am. Reply #

in deed anafranil is vry gud for sex but pls ppl dat knw more dan me. if u use it continuesly could it cure ur premature ejaculation finally?

by barry on December 7, 2016 at 12:12 am. Reply #

in deed dis drugs is amazing but can it finally cure premature ejaculation if taking continueslly?

by barry on December 7, 2016 at 12:19 am. Reply #

For all those who experience the humiliation of PE, this is the SOLUTION. This drug changed my life. It works. What an amazing thing to have sex and stay in total control. wow.

by Jeff on December 9, 2016 at 5:00 pm. Reply #

I have tried tadalafil but have not try on the magic wand anafranil
Though have heard so much about it,s wonders good luck pole and wish me luck as I try my hand on them.

by jagga nuel on January 10, 2017 at 12:08 pm. Reply #

My new girlfriend was not happy with the love we share together because I didn’t perform very well on bed. I can see it in her eyes but am afraid to lose her but a friend of mine told me about Anafranil. I want to invite her and try it. Thank you.

by Collins on January 15, 2017 at 4:33 pm. Reply #

This is a very good medication for us as we suffer PE and it has help me a lot. Thank you so much

by musa on February 11, 2017 at 5:16 am. Reply #

I took a small pill of anafranil last night,and the nauseous and dizzy feeling was terrible…even this morning, m still feeling a bit nauseous…I couldnt have sex cos my girl was on her period…but good thing is the drug works, but i wanna know if it also causes u to loose ur erection?

by Desmond on March 2, 2017 at 11:04 am. Reply #

The drug is good, but continuous taking of over-dose can be very fatal. Can cause magraine head-ache so pls people, consult your doctor before taking any drug u are not sure of.

by Nimi on March 8, 2017 at 12:50 am. Reply #

Please has anyone heard about PRILIGY i just got 3x 30mg from my doctor. Am suffering from PE for about 7yesrs i lost the only Girl i have ever loved.

by Kodi8 on March 22, 2017 at 5:13 pm. Reply #

Yeah, I wrote about Priligy a while ago you can read it here: Priligy (dapoxetine) for Premature Ejaculation
Sorry to hear about your girl.

by Frank DeLuca on March 23, 2017 at 10:16 am. Reply #

I can’t believe all you people are trying to use an antidepressant for this cause. I’ve known about this use for years and its unbelievable. Ive been taking it for 28 years and I’ve been trying to come of it for the past “2 years”. I’ve been tampering down but because my last dose was 6.25 mg, I am now “after 2 months” having severe withdrawal symptoms (discontinuation syndrome). Please be very, very careful you do not take this too regularly or on a daily basis because it will be very hard to come of it if your body gets used to it. There should be other ways to deal with PE, its not like its a disorder. I find it amazing how big pharmas accidentally find ways to push their meds!

by George Georgopoulos on March 30, 2017 at 4:47 pm. Reply #

Can one walk into any phamarcy and order for it without doctor’s prescription

by gentle on April 7, 2017 at 6:14 am. Reply #

Can u confirm any age limitations..?

by Johny on April 11, 2017 at 11:05 am. Reply #

Ideally it should not be used by individuals under 24, but always talk to your doctor before taking any antidepressants.

Some further information:

Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. In pooled data analyses, risk of suicidality was not increased in adults >24 years of age and apparently was reduced in adults ≥65 years of age with antidepressant therapy compared with placebo.

In pooled data analyses, risk of suicidality was not increased in adults >24 years of age and apparently was reduced in adults ≥65 years of age with antidepressant therapy compared with placebo.


Best of luck my friend. Take care.

by Frank DeLuca on April 11, 2017 at 11:15 am. Reply #

Let me give it a try

by Zulu boy on April 11, 2017 at 11:00 pm. Reply #

Can anafranil damage my sight

by Mikesr on April 18, 2017 at 2:21 pm. Reply #

I am 65 years old and so week in sexual power i heard about anafranil how much mg i can use and please tell me how many time before go to bed with my partner

by Ali on May 3, 2017 at 5:06 am. Reply #

For 65 years person how many mg can use and how much time before.

by Ali on May 3, 2017 at 5:10 am. Reply #

My friend introduce anafranil to me when I nearly lose a girl I lv in my life. I took anafranil 2hr before sex and believe what, she praised me with all sort of names in bed I lasted in bed having sex with her for about 4 to 5 hr and now I have her in my life.

by AUGUSTINE on June 14, 2017 at 11:01 pm. Reply #

Anafranil is a wonder drugs.

by Wisdom on June 19, 2017 at 3:41 pm. Reply #

Am 39 years old how many dose should I take

by Edward on July 19, 2017 at 9:49 pm. Reply #

Am 39 how mg should I take

by Edward on July 19, 2017 at 9:56 pm. Reply #

Am 33 and 25mg is perfect to me

by Anonymous on January 31, 2018 at 9:31 pm. Reply #

I am about to take anafranil which i got from the Men’s clinic the doctor told me to take 1 pill everday for 3 months (even if I’m not going to have sex) now i am scared to take them. What if my body get used to anafranil forever?

by Zane on July 31, 2017 at 8:56 pm. Reply #

Been suffering with PE for as long as I remember.
Have finally inlisted a professional for help and am currently on Zoloft which has now been 3 months.
Not feeling great and results aren’t great.
Back to the doc this Wednesday for a review but I’ll be asking about Anafranil and it’s affectness.
Anyone going through the same shit……. getting desperate

by Daryl on August 21, 2017 at 10:26 am. Reply #

I used dis medicine nd I enjoyed it perfectly but, It is taken me for more than four hours to release out….

by Bad boy on August 24, 2017 at 2:23 pm. Reply #


by DE JURE on September 27, 2017 at 3:22 am. Reply #


by DE JURE on September 27, 2017 at 3:25 am. Reply #

I used 50mg of Viagra but I didn’t last up to 5 mins with neauseatic effects.

Would anafralin solve my problem?

by Alfonso on December 17, 2017 at 5:08 pm. Reply #

It’s amazing how cool and great it always on bed

by Anonymous on January 31, 2018 at 9:29 pm. Reply #

Does anafranil cure pE permanently?

by Anonymous on March 1, 2018 at 7:25 pm. Reply #

Unfortunately not. It will work only as long as you keep taking it.

by Frank DeLuca on March 2, 2018 at 1:18 pm. Reply #

taking clomipramine is working for me,I am almost 60 years old,and I have had PE and ED for many years,I use it when I want to make love,I use only 10 mg,but it has a lot of side effects,mostly headache,but I have no choice ,I have read a lot of articles,I have tried all kind of foods,but they were not useful for me and the only medicine that worked for me was clomipramine or anafranil .I think changing your partner also is working,but I can’t make it sorry,because of many reasons.

by morad on March 19, 2018 at 2:02 pm. Reply #

its great for PE but the side effects though you will feel hot, have sleeping disorder and yawn too much

by king b on April 6, 2018 at 11:29 pm. Reply #

after going through now,i want to try 50mg,and see the result

by sunday ogholoh on May 12, 2018 at 12:12 am. Reply #

Good luck bro!

by Frank DeLuca on May 13, 2018 at 9:07 am. Reply #

Is it safe to use Anafranil with Sildenafil?

by Felix on June 6, 2018 at 5:12 pm. Reply #

anafranil works like magic.. 25mg and you on for hours. i used it to impress but not regularly. i live in pretoria and i get it without prescription. anyone want one email me on

by tshepo on July 13, 2018 at 2:57 pm. Reply #

I take 100mg of clomipramine every evening. My problem is I cant ejaculate at all. Is there an answer to this eg use Viagra take it slower.

by allen armstrong on July 16, 2018 at 12:57 am. Reply #

Am fifty years old. Been taking anaflanic now for fifteen years. It’s work wonders. But am not addicted to it, rather I don’t take it frequently. 50mlg

by Jackson Ville on July 21, 2018 at 7:09 pm. Reply #

I what to use it today and see if it work

by deeny on July 23, 2018 at 5:23 pm. Reply #

Is it safe when I’m planning a family?

by Its me on July 27, 2018 at 12:40 pm. Reply #

Can long time use of anafranil cause weak libido/Ed

by Stanley on August 15, 2018 at 3:24 am. Reply #

Does it damage your organs or any part of the body?

by Black on August 27, 2018 at 11:38 am. Reply #

I am happy

by Anonymous on August 29, 2018 at 3:41 pm. Reply #

im 20 years old and i popped anafranil 50mg i didnt ejaculate like i used to okay…. but i was losing my erection every now and then. very embarassing… i felt the 50mg was too much. should i go with 25mg?

yeah, the yawing, and sleeping disorder is one. thing that occurs too

by Jermaine on September 21, 2018 at 7:31 am. Reply #

Amazing article. Is there any chance a 10 milligram dose would work? I’d like to know how many hours to take it prior to sex and for those that have used it, what is the drug’s impact on erection?

by Anonymous mouse on September 26, 2018 at 4:41 pm. Reply #

when i use anafranil and have sex with my pregnant wife, will she or the baby be in any form of danger???

by kofi on September 28, 2018 at 8:32 pm. Reply #

Can Anafranil help me to get my Wife Pregnant & how long does erection last during sex

by Annonymous Devotion on October 9, 2018 at 1:15 pm. Reply #

Was on Paxil, but gave me diarrhea but worked great for PE. Now on anafranil 25 mg, works ok, may go up to 50 mg. And see results. Worried about addiction to anafranil.

by Booboobear on December 1, 2020 at 9:27 pm. Reply #

Thanks for sharing your experience.

by Frank DeLuca on December 15, 2020 at 11:04 pm. Reply #

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