Prozac for Premature Ejaculation

How To Use Prozac for Premature Ejaculation

Here’s how to use Prozac for premature ejaculation…

First of all, Prozac is the brand name for fluoxetine. I think it’s the oldest, and the best known of all SSRI antidepressants. It’s been around since 1980s, and doctors sometimes prescribe it for premature ejaculation.

It works by controlling the levels of serotonin (a chemical that controls your ejaculation), just like other SSRI antidepressants.

Another thing that shares with other SSRI antidepressants is that it’s legally available only by prescription. But, despite this regulation, some online pharmacies sell it without prescription.

Doctors usually recommend trying to take it as needed, 2 hours before having sex. If that doesn’t work, you’ll have to take it on a daily basis.

Most doctors start with giving you 10-20 mg per day. It can be one dose, or divided in two doses. If needed, the dose can be gradually increased, but it should not exceed 80 mg per day.

Prozac comes in a tablet form, and it’s taken orally. The food doesn’t affect it, so you can take it on an empty of full stomach.

If take-as-needed doesn’t work for you, and you take Prozac on a daily basis… you may need to wait 3 weeks before seeing improvement in your ejaculation control. If after 6 weeks there’s no improvement at all, or you experience some serious side effects, you doctor will probably end the therapy.

It that happens, you may try second SSRI antidepressant, such as Paxil or Zoloft. If the second doesn’t help, there’s usually no point in trying the third SSRI antidepressant.

However, you can try another type of antidepressant. They’re called tricyclic antidepressants, and the best known of them is Anafranil. It is interesting that Anafranil works better for premature ejaculation than SSRI antidepressants. But, it also has more side effects.

For more information see How to Use Anafranil for Premature Ejaculation.

Since Prozac is prescription-only drug, you should NEVER USE IT WITHOUT MEDICAL SUPERVISION. This becomes especially important if you’re already taking some medications, or if you have some health problems.

Here are some general warnings and precautions when using Prozac for premature ejaculation…

You should NOT use Prozac….

  • in combination with other type of antidepressants (MAOIs)
  • if you’re recovering from heart attack
  • if you have kidney or liver problems
  • if you have diabetes
  • if you have a history of seizures

Don’t drink alcohol while you’re taking Prozac.

Some common Prozac’s side effects are anxiety, insomnia, headaches, dizziness, changes in appetite, weight loss, nausea, and diarrhea.

Here’s the full-blown medical description of Prozac. It’s written by a doctor (and for doctors, but I thought you might want to take a look at it anyway).

Here it is…


Drug Name
Fluoxetine (Prozac) — Potent SSRI used to treat premature ejaculation. Improvement may not be evident until at least 3 wk following initiation of treatment. If no benefit with respect to premature ejaculation after 6 wk or if adverse effects become troublesome, discontinue in favor of alternative treatment.

Adult Dose
5-60 mg/d PO; most clinicians begin at 10-20 mg/d (in one dose or in two divided doses), or taken 2 h prior to intercourse as single-dose therapy; total daily dose not to exceed 80 mg/d

Pediatric Dose
Not established

Documented hypersensitivity; concomitant MAOIs or use within 14 d; thioridazine within 5 wk of discontinuation

Phenobarbital and phenytoin decrease effects; alcohol, cimetidine, sertraline, phenothiazines, and warfarin increase toxicity; additive CNS depressant effects with other antidepressants, opioid analgesics, sedatives, and hypnotics; increases toxicity of MAOIs; can alter levels of antidiabetic drugs (they may need adjustment); can alter levels of warfarin, digitalis, or both; may increase benzodiazepine, phenytoin, and carbamazepine levels; increased adverse effects with tryptophan; lithium levels can increase or decrease and need monitoring; may potentiate drugs metabolized by CYP2D6, antipsychotics (eg, haloperidol, clozapine), or other antidepressants; avoid alcohol, during or within 14 d of MAOIs, or within 5 wk of thioridazine discontinuation; caution with drugs that impair hemostasis (eg, nonselective NSAIDS, aspirin, warfarin) because of increased risk of bleeding

C – Safety for use during pregnancy has not been established.

Discontinue upon unexplained allergic reaction; monitor for symptoms of mania or hypomania; caution with diseases or conditions that could affect metabolism or hemodynamic responses, diabetes, history of seizures, suicidal tendencies; altered platelet function and hyponatremia reported; monitor for clinical worsening or suicidality, especially at initiation of therapy or dose changes; avoid abrupt withdrawal; monitor for discontinuation symptoms

Copyright © WebMD, By Mark Jeffrey Noble, MD, Urologic Institute, Cleveland Clinic Foundation, Retrieved from:

Again, you should never use Prozac for premature ejaculation without medical supervision because it’s a powerful drug.

Read this:


[…] more information on using Prozac and Zoloft for premature ejaculation see “How to use Prozac for premature ejaculation” and  “How to use Zoloft for premature […]

by How To Use Paxil for Premature Ejaculation on February 22, 2012 at 10:35 am. Reply #

[…] How To Use Prozac  for Premature Ejaculation […]

by How To Use Anafranil for Premature Ejaculation on February 22, 2012 at 11:04 am. Reply #

[…] (See  ”How To Use Paxil for Premature Ejaculation“,  and “How To Use Prozac for Premature Ejaculation“ ) […]

by How To Use Zoloft For Premature Ejaculation on February 22, 2012 at 11:12 am. Reply #

I was prescribed fluxetine 20mg by my doctor after
My marriage of 24 years broke down. One of the reasons i know was due to me having PE. This
Medication not only helped with the depression
I was suffering with but ironically cured and i mean totally the PE id suffered with for decades.
I can not stress enough if you suffer with PE try fluxetine, give it two to three weeks to get in to your system. I haven’t looked back :-)

by Chris on November 30, 2016 at 9:39 pm. Reply #

you said you’d never looked back.
do you mean even after you stopped taking fluoxétine??
i used to take anafranil for PE, but i only took one 20mg pill before any sexual intercourse and it really helped. but i noticed i always had to take it whenever i was going to have sex. otherwise ejaculation won’t last more than 20 seconds. i have never tried fluexitine before. but i would like to know if it would cure my PE if i take it daily for a few weeks. i mean even when i stop taking it after that?
could you please answer me to my email
thanks a lot

by faissal on October 30, 2017 at 1:01 pm. Reply #

i suffer from PE. and really need fluxetine availible in south africa?

by willie on April 12, 2017 at 4:43 pm. Reply #

how long can i take this prozac to manage my problem of premature ejaculation

by fox on May 6, 2017 at 1:28 pm. Reply #

Can I get some to buy in Ghana?

by Anonymous on June 25, 2017 at 11:39 am. Reply #

Yes you can get it in Ghana but it’s not common and you need a Prescription for it. Need help get it pls contact Laud K Pharmacy in Kumasi

by Awadada on September 4, 2017 at 7:04 pm. Reply #

Try dapavor its all natural and it increase serotonin! Also my duration spray which you can find at your local Walmart!

by Todd on August 29, 2017 at 7:29 pm. Reply #

Leave your comment