Zoloft for premature ejaculation

How To Use Zoloft For Premature Ejaculation

Here’s what you need to know before using Zoloft for premature ejaculation…

Zoloft is the brand name for a drug called sertraline.

It’s a strong SSRI antidepressants that some doctors prescribe for premature ejaculation.

It works by adjusting the levels of serotonin in the brain. (Serotonin is a chemical that carries messages between your brain cells.)

In men who suffer from premature ejaculation, the serotonin seems to be less active in the section of the brain that controls ejaculation. Zoloft increases the levels of serotonin, and thus enables you to delay your ejaculation and last longer.

Zoloft is legally available only by prescription, but some online pharmacies sell it without prescription.

Tablets are first taken as needed, 2 to 12 hours before having sex.

If that fails, than you take them on a daily basis – once a day, with or without food. The starting dose is 50 mg. Your doctor may slowly increase the dose, if needed, to a maximum daily dose of 200 mg.

When you use Zoloft on a daily basis, you may need to wait 3 or more weeks to see improvements. If there’s no improvement after 6 weeks (from the beginning), or if you experience too much negative side effects, your doctor will probably end the treatment.

If Zoloft doesn’t work for you, your doctor may prescribe another SSRI antidepressant to try again. For example, Paxil or Prozac. However, if the second SSRI fails too, trying the third probably won’t help you much.

(See  “How To Use Paxil for Premature Ejaculation“,  and “How To Use Prozac for Premature Ejaculation” )

But, don’t quit on yourself if that happens to you. That doesn’t mean that you can’t be cured, it only means that SSRI antidepressants don’t work for you. There are plenty of other options for you.

Your doctor may prescribe another type of antidepressant, a tricyclic antidepressant such as Anafranil. Many researchers have found that Anafranil is more effective for premature ejaculation than SSRIs, but Anafranil tends to have more side effects. (See  “How To Use Anafranil for Premature Ejaculation“)

Zoloft is a serious drug that can damage your health if used improperly. You should not use it without medical supervision. This is especially true if you are already taking some medications (or have recently do so), or if you have some health issues.

Here are some precautions you need to be aware of when using Zoloft for premature ejaculation…

You should use Zoloft with caution if…

  • you have problems with liver or kidneys
  • you have Parkinson disease,
  • you have seizures
  • you recently had a heart attack

You should not use Zoloft with alcohol.

And, Zoloft can cause problems when used with other medications. Such as…

  • various diabetes medications, including insulin
  • certain type of antidepressants (MAOIs, or monoamine oxidase inhibitors)
  • and some other medications such as Valium (diazepam), Coumadin (warfarin), Tagamet (cimetidine), and others

Zoloft may have some negative side effects. Some of them are headache, agitation, fatigue, insomnia, sleepiness, constipation, diarrhea, vomiting, a dry mouth, sweating, irregular heartbeat, tremors, difficulty breathing or swallowing, sensitivity to bright light, weight loss, or behavioral changes.

Some minor side effects are expected in first couple of days of using antidepressants. It’s a normal reaction of your body while it’s adjusting to medication.

And, to wrap this up…

I’ll give you a full medical description of Zoloft from eMedicine.com. It’s a doctor speak, so don’t worry if you don’t understand everything. This sort of stuff your doctor will read if he wants to refresh his memory before prescribing you Zoloft.

Here it is…


Drug Name
Sertraline (Zoloft) — Potent SSRI used to treat premature ejaculation. Improvement may not be evident until at least 3 wk following initiation of treatment. If no benefit with respect to premature ejaculation after 6 wk or if adverse effects become troublesome, discontinue in favor of alternative treatment.

Adult Dose
50 mg PO 2-12 h before sexual relations; alternatively, 50 mg/d PO; gradually titrate to response; not to exceed 200 mg/d

Pediatric Dose
Not established

Documented hypersensitivity; concomitant MAOIs or use within 14 d

Increases toxicity of MAOIs, diazepam, tolbutamide, and warfarin; additive CNS effects with alcohol, antidepressants, opioid analgesics, sedatives, and hypnotics; suspension contains alcohol and, therefore, is contraindicated in patients taking disulfiram (Antabuse)

C – Safety for use during pregnancy has not been established.

Caution in recent MI or unstable heart disease; hyponatremia; although minimal adverse anticholinergic effects (compared with TCAs), use with caution in glaucoma, bladder outlet obstruction, chronic constipation, and other conditions in which adverse anticholinergic effects may exacerbate symptoms; caution in patients with moderate-to-severe renal or hepatic impairment, because of excessive blood level accumulation, adjust dose accordingly; does not impair motor or cognitive ability with respect to performance of complex tasks, nor does it cause somnolence, but any drug affecting the CNS may cause drowsiness, and driving and performance of other tasks requiring alertness and concentration should be avoided; seizures are rare, use with caution in preexisting seizure disorder; when used for premature ejaculation (off-label), patients with clinical depression should be treated by a mental health care professional, potential for depressed patients to commit suicide; priapism has been (rarely) reported

Copyright © WebMD, By Mark Jeffrey Noble, MD, Urologic Institute, Cleveland Clinic Foundation, Retrieved from: http://www.emedicine.com/med/topic643.htm

Using Zoloft for premature ejaculation can be very effective treatment. But it should always be done under medical supervision.

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[…] Zoloft for premature ejaculation  […]

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by New Treatments For Depression » Blog Archive Comments On Zoloft From Users on November 12, 2014 at 11:36 am. Reply #

Which kind of Doctor can I go to if I have this problam of premature ejuculation? Please I need help

by Phindile on February 20, 2015 at 6:20 am. Reply #

I used zoloft many year ago. It works I recommend 100% your wife will thank you.

by cali on April 10, 2015 at 6:26 pm. Reply #

Does Zoloft fix the problem forever? Or you go back to PE when you stop the treatment?

by Tom on October 6, 2015 at 8:53 pm. Reply #

Sadly, no. When you stop taking Zoloft PE comes back. Same thing with other SSRI antidepressants like Paxil, Prozac, etc.

by Frank DeLuca on October 8, 2015 at 7:28 am. Reply #


by Danny on May 28, 2015 at 8:48 pm. Reply #

i suffer from severe PE and weak erection. Doc prescribed anafranil which i used, it worked like magic. problem is, after about a month; it stopped working. EVen if use the drug now, it has no effect. any advice on what i can do?

by segun on August 7, 2016 at 12:45 am. Reply #

You can try with some other pills, prescription or over the counter. If you go with prescription drugs do see your doctor, don’t do it on your own. If Anafranil is no longer working your doctor can prescribe you some SSRIs like Zoloft, Pacil, Prozac and the like. Or you can try some over the counter stuff and see how that goes, or try some exercises like start-stop and stuff. Don’t worry, it’s not that uncommon that one thing doesn’t work and the next does. Good luck!

by Frank DeLuca on August 17, 2016 at 7:20 pm. Reply #

How long can a zoloft be active on my body

by Dumi on March 27, 2017 at 11:14 pm. Reply #

thanks u very much for all

by zaheer ud din babar on April 6, 2017 at 8:31 am. Reply #

Zoloft drugs does it work to improve erection or strictly for PE any advice in response to use of this zoloft

by Princo on July 1, 2017 at 10:13 pm. Reply #

I don’t think Zoloft can help with erection

by Frank DeLuca on July 2, 2017 at 11:34 am. Reply #

For years I’ve been dealing with PE and now my wife is Fed up with me. Will Zoloft have a immediate result? Help me losing my the love of my life.

by Anonymous on July 23, 2017 at 11:59 am. Reply #

If your wife is fed up with you because of P.E then you need to get rid of her. She is selfish and not very understanding. Sex is small part of marriage. Love for one another will never be broken.

by Lar on September 10, 2017 at 3:12 pm. Reply #

Continue use of zoloft can cause erectile dysfunction.
Use it according to ur need.

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by LastKerry on January 26, 2018 at 6:27 am. Reply #

Ideal treatment for erectile dysfunction zolft I’m using since last two month miracle drug for erectile function appreciate it how much can use?

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Ideal treatment for erectile dysfunction zolft I’m using since last two months

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